Targeted pain relief, backed by science
Pain relief
Targeted vagus nerve stimulation designed to help ease discomfort and improve quality of life.
Inflammation control
Supports the body’s natural processes involved in regulating inflammatory responses.
Scientifically proven
Developed from decades of our research in neuroimmunology and bioelectronic medicine.
Turning neuroscience into pain relief
Cymbathera is a bioelectronic product company, built on decades of neuroimmunology research by our world-leading scientists at Feinstein Institute for Medical Research Northwell Health and the Karolinska Institutet. Our founders created Cymbathera because chronic pain and inflammation affect millions of people—and current solutions often rely on long-term medication with adverse effects, or incomplete relief. Modern science has proven that the body already has a powerful, drug-free regulatory system: the vagus nerve system.
Our work focuses on translating this science into a non-invasive medical device currently under clinical and regulatory evaluation. By targeting vagus nerve signaling, we aim to support the body’s natural ability to regulate inflammation and pain—and without systemic side effects. Our purpose: to translate clinically proven neuroscience into accessible, safe bioelectronic solutions to help as many people as possible move toward a life with less pain, less inflammation, and more balance.
Living with pain or inflammation can affect everyday life.
Advances in bioelectronic medicine are expanding our understanding of the body’s natural pathways. Cymbathera is developing a non‑invasive bioelectronic medical device informed by decades of vagus nerve research.
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Cymbathera is an investigational medical device and is not currently available for clinical or commercial use. The device has not been approved or cleared by any regulatory authority. Information provided on this website is for general informational purposes only and does not constitute medical advice.
The vagus nerve and immune regulation
The vagus nerve plays a central and critical role in regulating inflammation, pain and recovery. Over the past 25 years, extensive research led and performed by our Founders at the Karolinska Institutet and the Feinstein Institute for Medical Research Northwell Health has shown that the nervous system actively controls immunes responses through a mechanism known as the inflammatory reflex, this can be therapeutically activated and regulated using vagus nerve stimulation.
Over 25 years of foundational neuroimmune research by each of our Founders
Pain studies using vagus nerve stimulation
Inflammation studies using vagus nerve stimulation
Founders
Cymbathera was founded by a multidisciplinary team of leading scientists and industry experts in neuroimmunology, bioelectronic medicine, and medical technology. Among the founders is Professor Kevin Tracey, discoverer of the inflammatory reflex, together with senior clinicians and innovators with decades of experience translating fundamental science into clinically validated therapies.
Ulf Andersson
Professor of Pediatric Rheumatology at Karolinska Institutet with over five decades of experience in clinical and inflammation research. Long-standing collaboration with Kevin Tracey on vagus nerve stimulation and treatment of inflammatory conditions. Honorary Doctorate from Hofstra University - Northwell Health and Highly Cited Clarivate Researcher.
Kevin Tracey
Kevin J. Tracey, MD, is President and CEO of the Feinstein Institutes for Medical Research and Professor of Neurosurgery and Molecular Medicine at the Zucker School of Medicine at Hofstra/Northwell. A pioneer in bioelectronic medicine. He discovered the inflammatory reflex, a neural circuit through which the vagus nerve regulates immune responses, laying the foundation for FDA-approved, non-drug therapies for inflammatory diseases. In 2026, he was named an “Innovator” on the TIME100 Health List for transforming global health through neural technology. Recognized as one of the world’s most highly cited scientists in vagus nerve research, he holds more than 120 U.S. patents and has authored over 450 scientific publications. He is a Fellow of the National Academy of Inventors and the Royal Swedish Academy of Engineering Sciences.
Clinical Areas
Rheumatoid arthritis, chronic pain, inflammatory bowel disease, and Long COVID are conditions linked by persistent inflammation and nervous system imbalance. They commonly cause pain, fatigue, and reduced quality of life, often lasting months or years and requiring long-term, supportive treatment approaches.
Rheumatoid Arthritis (RA)
Targeting vagus-nerve pathways may help modulate immune activity and reduce inflammatory signaling.
Chronic Pain
Persistent pain is often linked to dysregulated inflammatory and neural pathways.
Long COVID
Vagus nerve dysfunction may impair the body’s ability to shut down inflammation.
Inflammatory Bowel Disease
Conditions like Crohn’s disease and ulcerative colitis involve chronic gut inflammation.
FAQs
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